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Dr Tim Van Langenhove

BMedSc UGent, MA UGent, PhD UAntwerp.

Associate Investigator

Contact Details

email : tim.vanlangenhove@gmail.com

External Address

Department of Neurology, Ghent University Hospital, Belgium and
VIB-UAntwerp Center for Molecular Neurology, Belgium

Selected Publications

Periodicals

  • Van Langenhove, T., Piguet, O., Burrell, J.R., Leyton, C., Foxe, D., Abela, M., Bartley, L., Kim, W.S., Jary, E., Huang, Y., Dobson-Stone, C., Kwok, J.B., Halliday, G.M., & Hodges, J.R. (2017). Predicting development of amyotrophic lateral sclerosis in frontotemporal dementia. Journal of Alzheimer's Disease, 58, 163-170. doi:10.3233/JAD-161272
  • Van Langenhove, T., Leyton, C.E., Piguet, O., & Hodges, J.R. (2016). Comparing longitudinal behavior changes in the primary progressive aphasias. Journal of Alzheimer's Disease, 53(3), 1033-1042. doi:10.3233/JAD-160010
  • Cuyvers, E., Bettens, K., Philtjens, S., Van Langenhove, T., Gijselinck, I., van der Zee, J., Engelborghs, S., Vandenbulcke, M., Van Dongen, J., Geerts, N., Maes, G., Mattheijssens, M., Peeters, K., Cras, P., Vandenberghe, R., et al. (2014). Investigating the role of rare heterozygous TREM2 variants in Alzheimer disease and frontotemporal dementia. Neurobiology of Aging, 35(3), 729. doi:10.1016/j.neurobiolaging.2013.09.009
  • Ferrari, R., Hernandez, D.G., Nalls, M.A., Rohrer, J.D., Ramasamy, A., Kwok, J.B.J., Dobson-Stone, C., Brooks, W.S., Schofield, P.R., Halliday, G., Hodges, J., Piguet, O., Van Langenhove, T., et al. (2014). Frontotemporal dementia and its subtypes: A genome wide association study. Lance Neurology, 13(7), 686-699.
  • Gallagher, M.D., Suh, E., Grossman, M., Elman, L., McCluskey, L., Van Swieten, J.C., Al-Sarraj, S., Neumann, M., Gelpi, E., Ghetti, B., Rohrer, J.D., Halliday, G., Van Broeckhoven, C., Seilhean, D., Shaw, P.J., Frosch, M.P., Van Langenhove, T., et al. (2014). TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathologica, 127(3), 407-418.
  • van der Zee, J., Van Langenhove, T., Kovacs, G.G., Dillen, L., Deschamps, W., Engelborghs, S., Matej, R., Vandenbulcke, M., Sieben, A., Dermaut, B., Smets, K., BELNEU consortium, EU EOD consortium, et al. (2014). Rare mutations in SQSTM1 modify susceptibility for frontotemporal lobar degeneration. Acta Neuropathologica, 128, 397-410.
  • Cruts, M., Gijselinck, I., Van Langenhove, T., van der Zee, J., & Van Broeckhoven, C. (2013). Current insights into the C9orf72 repeat expansion diseases of the FTLD/ALS spectrum. Trends in Neurosciences, 36(8), 450-459.
  • Dillen, L., Van Langenhove, T., Engelborghs, S., Vandenbulcke, M., Sarafov, S., Tournev, I., Merlin, C., Cras, P., Vandenberghe, R., De Deyn, P., Jordanova, A., Cruts, M., Van Broeckhoven, C., van der Zee, J., BELNEU consortium. (2013). Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of Frontotemporal Lobar Degeneration patients. Neurobiology of Aging, 34(6), 1711. doi:10.1016/j.neurobiolaging.2012.12.007
  • van der Zee, J., Gijselinck, I., Dillen, L., Van Langenhove, T., Theuns, J., Engelborghs, S., Philtjens, S., Vandenbulcke, M., Sleegers, K., Sieben, A., et al. on behalf of the European Early-Onset Dementia (EOD) Consortium (2013). A Pan-European study of the C9orf72 repeat associated with FTLD: Geographic prevalence, genomic instability and intermediate repeats. Human Mutation, 34(2), 363-373.
  • Van Langenhove, T., van der Zee, J., Gijselinck, I., Engelborghs, S., Vandenberghe, R., Vandenbulcke, M., De Bleecker, J., Sieben, A., Versijpt, J., Ivanoiu, A., Deryck, O., Willems, C., Dillen, L., Philtjens, S., Maes, G., Bäumer, V., et al. (2013). Distinct clinical characteristics of C9orf72 expansion carriers compared to GRN, MAPT and non-mutation carriers in a Flanders-Belgian FTLD cohort. JAMA Neurology, 70(3), 365-373.
  • Van Langenhove, T., van der Zee, J., Engelborghs, S., Vandenberghe, R., Santens, P., Van den Broeck, M., Mattheijssens, M., Peeters, K., Nuytten, D., Cras, P., et al. (2012). Ataxin-2 polyQ expansions in FTLD-ALS spectrum disorders in Flanders-Belgian cohorts. Neurobiology of Aging, 33(5), 1004. doi:10.1016/j.neurobiolaging.2011.09.025
  • Gijselinck, I., Van Langenhove, T., van der Zee, J., Sleegers, K., Philtjens, S., Kleinberger, G., Janssens, J., Bettens, K., Van Cauwenberghe, C., Pereson, S., Engelborghs, S., Sieben, A., et al. (2012). A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: A gene identification study. Lancet Neurology, 11(1), 54-65.
  • Sieben, A., Van Langenhove, T., Engelborghs, S., Martin, J-J., Boon, P., Cras, P., De Deyn, P., Santens, P., Van Broeckhoven, C., Cruts, M. (2012). The genetics and neuropathology of frontotemporal lobar degeneration. Acta Neuropathologica, 124(3), 353-372.
  • Van Langenhove, T., van der Zee, J., Van Broeckhoven, C. (2012). The molecular basis of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum. Annals of Medicine, 44(8), 817-828.
  • van der Zee, J., Van Langenhove, T., Kleinberger, G., Sleegers, K., Engelborghs, S., Vandenberghe, R., Santens, P., Van den Broeck, M., Joris, G., Brys, J., Mattheijssens, M., et al. (2011). TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort. Brain, 134, 808-815.

Conference Presentations, Colloquia, and other presentations

  • Van Langenhove, T., Leyton, C.E., Piguet, O., & Hodges, J.R. (2015, November). Differences in prevalence and course of behaviour changes between subtypes of primary progressive aphasia. Poster session presented at the ARC Centre of Excellence in Cognition and its Disorders Annual Workshop, Macquarie University, Sydney.
  • Van Langenhove, T., Leyton, C.E., Piguet, O., & Hodges, J.R. (2015, October). Differences in the prevalence and course of behaviour changes between subtypes of primary progressive aphasia. Poster session presented at the Asia Pacific FTD/MND (APFM) Meeting, The University of Sydney, Sydney.
  • Van Langenhove, T., van der Zee, J., Gijselinck,I. , Engelborghs,S ., Vandenberghe,R. , Vandenbulcke, M., De Bleecker, J., Sieben, A., Versijpt, J., Ivanoiu, A., Deryck, O., Willems, C., Dillen, L., Philtjens, S., Maes, G., Bäumer, V., Van den Broeck, M., (2012, September). Distinct clinical characteristics of C9orf72 expansion carriers compared to GRN, MAPT and nonmutation carries in a Flanders-Belgian FTLD cohort. Poster session presented at the 8th International Conference on Frontotemporal Dementia’s, Manchester, UK.

Further Information

Contact Details

Telephone: +61 2 9850 4127
Email : ccd@mq.edu.au
Web : www.ccd.edu.au

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