Skip to Content

Dr James Burrell

BSc, MBBS UNSW, BA UNSW, PhD UNSW, FRACP.

Associate Investigator

Contact Details

Phone : +61 2 9351 3132
email : james.burrell@sydney.edu.au
Homepage : http://sydney.edu.au/medicine/people/academics/profiles/james.burrell.php
ORCID : http://orcid.org/0000-0001-9638-2768

External Address

Brain and Mind Centre
The University of Sydney

Profile

Dr Burrell's research focuses on the overlaps between frontotemporal dementia and motor neuron disease, as well as using neurophysiological and imaging biomarkers to link clinical symptoms and pathology in atypical dementia syndromes.

Awards

  • UNSW School of Medical Sciences, Paper of the Month Award (2014), Kumfor, F., Sapey-Triomphe, L.-A., Leyton, C.E., Burrell, J.R., Hodges, J.R., & Piguet, O. For the publication: Kumfor, F., et al. (2014) "Degradation of emotion processing ability in corticobasal syndrome and Alzheimer's disease" in Brain.

Recent Grants Awarded

  • NHMRC Early Career Fellowship [APP1072451] (2014 - 2017) "Language deficits and cognitive dysfunction in Motor Neuron Disease." Burrell, J. ($255,217)
  • The Servier Staff 'Barry Young' Research Establishment Fellowship (2014) "The characteristics and implications of language dysfunction in motor neuron disease." Burrell, J. ($50,000)
  • Pfizer Neuroscience Research Grant (2013) "Detecting cognitive impairment in motor neuron disease." Burrell, J. R. ($34,736)
  • Motor Neurone Disease Research Institute of Australia Grant in aid (2013) Burrell, J. R. ($97,009)
  • Motor Neurone Disease Research Institute of Australia (MNDRIA) (2013 - 2014) "The impact of language dysfunction on patient quality of life and carer burden in motor neuron disease." Burrell, J., Mioshi, E., Hornberger, M., & Ballard, K.J. ($97,009)
  • Motor Neurone Disease Research Institute of Australia (2013) "Impact of language dysfunction on patient quality of life and carer burden in Motor Neurone Disease: Implications for future therapies." Burrell, J.R., Mioshi, E., Hornberger, M., & Ballard, K. ($97,000)

Selected Publications

Periodicals

  • Silsby, M., Tweedie-Cullen, R.Y., Murray, C.R., Halliday, G.M., Hodges, J.R., & Burrell, J.R. (In Press). The midbrain-to-pons ratio distinguishes progressive supranuclear palsy from non-fluent primary progressive aphasias. European Journal of Neurology. doi:10.1111/ene.13314
  • Van Langenhove, T., Piguet, O., Burrell, J.R., Leyton, C., Foxe, D., Abela, M., Bartley, L., Kim, W.S., Jary, E., Huang, Y., Dobson-Stone, C., Kwok, J.B., Halliday, G.M., & Hodges, J.R. (2017). Predicting development of amyotrophic lateral sclerosis in frontotemporal dementia. Journal of Alzheimer's Disease, 58, 163-170. doi:10.3233/JAD-161272
  • Bae, J.S., Ferguson, M., Tan, R., Mioshi, E., Simon, N., Burrell, J., Vucic, S., Hodges, J.R., Kiernan, M.C., & Hornberger, M. (2016). Dissociation of structural and functional integrities of the motor system in amyotrophic lateral sclerosis and behavioral-variant frontotemporal dementia. Journal of Clinical Neurology, 12(2), 209-217. doi:10.3988/jcn.2016.12.2.209
  • Burrell, J.R., Forrest, S., Bak, T.H., Hodges, J.R., Halliday, G., & Kril, J.J. (2016). Expanding the phenotypic associations of globular glial tau subtypes. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 4, 6-13. doi:10.1016/j.dadm.2016.03.006
  • Burrell, J.R., Halliday, G.M., Kril, J.J., Ittner, L.M., Gotz, J., Kiernan, M.C., & Hodges, J.R. (2016). The frontotemporal dementia-motor neuron disease continuum. The Lancet, 388(10047), 919-931. doi:10.1016/S0140-6736(16)00737-6
  • Foxe, D., Leyton, C.E., Hodges, J.R., Burrell, J.R., Irish, M., & Piguet, O. (2016). The neural correlates of auditory and visuospatial span in logopenic progressive aphasia and Alzheimer's disease. Cortex, 83, 39-50. doi:10.1016/j.cortex.2016.07.003
  • Hsieh, S., Caga, J., Leslie, F., Shibata, M., Daveson, N., Foxe, D., Ramsey., E., Lillo., P., Ahmed, R., Devenney, E., Burrell, J.R., Hodges, J.R., Kiernan, M.C., & Mioshi, E. (2016). Cognitive and behavioural symptoms in ALSFTD: Detection, differentiation and progression. Journal of Geriatric Psychiatry and Neurology, 29(1), 3-10. doi:10.1177/0891988715598232
  • Kamminga, J., Leslie, F.V.C., Hsieh, S., Caga, J., Mioshi, E., Hornberger, M., Ballard, K.J., Kiernan, M.C., Hodges, J.R., & Burrell, J.R. (2016). Syntactic comprehension deficits across the FTD-ALS continuum. Neurobiology of Aging, 41, 11-18. doi:10.1016/j.neurobiolaging.2016.02.002
  • Burrell, J.R., & Piguet, O. (2015). Lifting the veil: How to use clinical neuropsychology to assess dementia. Journal of Neurology, Neurosurgery & Psychiatry, 86, 1216-1224. doi:10.1136/jnnp-2013-307483
  • De Silva, D., Hsieh, S., Caga, J., Leslie, F.V.C., Kiernan, M.C., Hodges, J.R., Mioshi, E., & Burrell, J.R. (2015). Motor function and behaviour across the ALS-FTD spectrum. Acta Neurologica Scandinavica, 9(2), 203-218. doi:10.1111/ane.12471
  • Kamminga, J., Kumfor, F., Burrell, J.R., Piguet, O., Hodges, J.R., & Irish, M. (2015). Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: An examination of clinical characteristics and emotion processing. Journal of Neurology, Neurosurgery & Psychiatry, 86(10), 1082-1088. doi:10.1136/jnnp-2014-309120
  • Leslie, F.V.C., Hsieh, S., Caga, J., Savage, S.A., Mioshi, E., Hornberger, M., Kiernan, M.C., Hodges, J.R., & Burrell, J.R. (2015). Semantic deficits in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16, 46–53. doi:10.3109/21678421.2014.987301
  • Taswell, C., Villemagne, V.L., Yates, P., Shimada, H., Leyton, C.E., Ballard, K.J., Piguet, O., Burrell, J.R., Hodges, J.R., & Rowe, C.C. (2015). FDG-PET improves diagnosis in patients presenting with focal onset dementias. The Journal of Nuclear Medicine, 56, 1547-1553. doi:10.2967/jnumed.115.161067
  • Burrell, J.R., Hodges, J.R., & Rowe, J.B. (2014). Cognition in corticobasal syndrome and progressive supranuclear palsy: A review. Movement Disorders, 29(5), 684-693. doi:10.1002/mds.25872
  • Burrell, J.R., Hornberger, M., Vucic, S., Kiernan, M.C., & Hodges, J.R. (2014). Apraxia and motor dysfunction in corticobasal syndrome. PLoS ONE, 9(3), e92944. doi:10.1371/journal.pone.0092944
  • Burrell, J.R., Parratt, K., & Lueck, C.J. (2014). Job variation in advanced training in adult neurology in Australia and New Zealand: A follow-up study. Internal Medicine Journal, 44(6), 554-561. doi://10.1111/imj.12413
  • Devenney, E., Hornberger, M., Irish, M., Mioshi, E., Burrell, J., Tan, R., Kiernan, M., & Hodges, J.R. (2014). Frontotemporal dementia associated with the C9ORF72 mutation: A unique clinical profile. JAMA Neurology, 71(3), 331-339. doi:10.1001/jamaneurol.2013.6002
  • Geevasinga, N., Burrell, J.R., Hibbert, M., Vucic, S., & Ng, K. (2014). C9ORF72 familial motor neuron disease - frontotemporal dementia associated with lung adenocarcinoma and anti-Ma2/Ta antibodies: A chance association? European Journal of Neurology, 21(4), e31-e33. doi:10.1111/ene.12347
  • Huang, N., Hornberger, M., Hodges, J.R., & Burrell, J.R. (2014). Measuring disease progression in corticobasal syndrome. Journal of Neurology, 261, 1598-1605. doi:10.1007/s00415-014-7389-5
  • Kumfor, F., Sapey-Triomphe, L.-A., Leyton, C.E., Burrell, J.R., Hodges, J.R., & Piguet, O. (2014). Degradation of emotion processing ability in corticobasal syndrome and Alzheimer’s disease. Brain, 137(11), 3061-3072. doi:10.1093/brain/awu246
  • Po, K., Leslie, F.V.C., Gracia, N., Bartley, L., Kwok, J.B.J., Halliday, G.M., Hodges, J.R., & Burrell, J.R. (2014). Heritability in frontotemporal dementia: More missing pieces? Journal of Neurology, 261(11), 2170-2177. doi:10.1007/s00415-014-7474-9
  • Burrell, J., Hornberger, M., Villemagne, V., Rowe, C., & Hodges, J.R. (2013). Clinical profile of PiB-positive corticobasal syndrome. PLoS ONE, 8(4), e61025. doi:10.1371/journal.pone.0061025
  • Burrell, J.R, Carpenter, R.H.S., Hodges, J.R., & Kiernan, M.C. (2013). Early saccades in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14, 294–301.
  • Cushing, N., Jang, J., O'Connor, C.M., Burrell, J.R., Clemson, L., Hodges, J.R., & Mioshi, E. (2013). Disability in atypical parkinsonian syndromes is more dependent on memory dysfunction than motor symptoms. Parkinsonism & Related Disorders, 19(4), 436-40. doi:10.1016/j.parkreldis.2013.01.002
  • Burrell, J.R., Hornberger, M., Carpenter, R.H.S., Kiernan, M., & Hodges, J.R. (2012). Saccadic abnormalities in frontotemporal dementia and amyotrophic lateral sclerosis. Neurology, 78, 1816-1823.
  • Leyton, C.E., Piguet, O., Savage, S., Burrell, J., & Hodges, J.R. (2012). The neural basis of Logopenic Progressive Aphasia. Journal of Alzheimer's Disease, 32(4), 1051–1059.
  • Lillo, P., Mioshi, E., Burrell, J., Kiernan, M., Hodges, J.R., & Hornberger, M. (2012). Grey and white matter changes across the amyotrophic lateral sclerosis-frontotemporal dementia continuum. PLoS One, 7(8), e43993.
  • Burrell, J., Kiernan, M.C., Vucic, S., & Hodges, J.R. (2011). Motor neuron dysfunction in frontotemporal dementia. Brain, 134(9), 2582-2594.
  • Leyton, C.E., Villemagne, V.L., Savage, S., Pike, K.E., Ballard, K.J., Piguet, O., Burrell, J.R., Rowe, C.C., & Hodges, J.R. (2011). Subtypes of progressive aphasia: Application of the international consensus criteria and validation using B-amyloid imaging. Brain, 134(10), 3030-3043.

Published Abstracts

  • Leyton, C., Landin-Romero, R., Kumfor, F., Burrell, J., Hodges, J.R., & Piguet, O. (2016). Convergent language network involvement in non-semantic PPA variants [Abstract]. Journal of Neurochemistry, 138(Suppl. 1), 352. doi:10.1111/jnc.13692
  • Kumfor, F., Kamminga, J., Burrell, J., Piguet, O., Hodges, J.R., & Irish, M. (2014). Divergent neural regions underpin emotion processing deficits in right-lateralised semantic dementia and behavioural-variant frontotemporal dementia [Abstract]. American Journal of Neurodegenerative Disorders, 3(Suppl. 1), 229.
  • Taswell, C., Villemagne, V., Yates, P., Shimada, H., Leyton, C., Ballard, K., Piguet, O., Burrell, J., Hodges, J., & Rowe, C. (2014). FDG-PET improves diagnosis in patients presenting with focal onset variants of Alzheimer’s disease [Abstract]. The Journal of Nuclear Medicine, 55(Suppl. 1), 194.

Conference Presentations, Colloquia, and other presentations

  • Kumfor, F., Kamminga, J., Burrell, J., Piguet, O., Hodges, J.R., & Irish, M. (2014, October). Divergent neural regions underpin emotion processing deficits in right-lateralised semantic dementia and behavioural-variant frontotemporal dementia. Poster session presented at the 9th International Conference on Frontotemporal Dementias, Vancouver, Canada.
  • Burrell, J., Hornberger, M., Carpenter, R., Kiernan, M., & Hodges, J.R. (2012, September). Disinhibition of “early” saccades in frontotemporal dementia. Poster session presented at the 8th International Conference on Frontotemporal Dementias, Manchester, UK.
  • Burrell, J., Hornberger, M., Villemagne, V., Rowe, C., & Hodges, J.R. (2012, September). Clinical features of corticobasal syndrome due to Alzheimer's pathology. Poster session presented at the 8th International Conference on Frontotemporal Dementias, Manchester, UK.
  • Leyton, C., Piguet, O., Savage, S., Burrell, J., & Hodges, J.R. (2012, September). Neural correlates of impaired naming and repetition in logopenic progressive aphasia. Poster session presented at the 8th International Conference on Frontotemporal Dementias, Manchester, UK.
  • Lillo, P., Mioshi, E., Burrell, J., Kiernan, M., Hodges, J.R., & Hornberger, M. (2012, September). The FTD-ALS continuum: Evidence from grey and white matter neuroimaging. Poster session presented at the 8th International Conference on Frontotemporal Dementias, Manchester, UK.
  • Burrell, J., Hornberger, M., Carpenter, R., Kiernan, M., Hodges, J.R. (2011, November). Saccadic eye movements in Motor Neuron Disease and Frontotemporal Dementia. Poster session presented at the 22nd International Symposium on ALS/MND, Sydney.
  • Burrell, J., Kiernan, M., Vucic, S., Hodges, J.R. (2011, November). Clinical and neurophysiological evidence of Motor Neuron Dysfunction in Frontotemporal Dementia. Poster session presented at the 22nd International Symposium on ALS/MND, Sydney.
  • Burrell, J., Hornberger, M., Carpenter, R., Kiernan, M., Hodges, J.R. (2011, October). Abnormal Saccades Detect Frontal Dysfunction in Motor Neuron Disease. Poster session presented at the Australian and New Zealand Association of Neurologists (ANZAN) clinical neurophysiology workshop, Gold Coast, Australia.
  • Burrell, J.R., Vucic, S., Kiernan, M.C., & Hodges, J.R. (2011, May). Motor dysfunction in Frontotemporal Dementia. Presentation given at the Australian and New Zealand Association of Neurologists (ANZAN) Annual Scientific Meeting, Hobart, Australia.
  • Burrell, J.R., Kiernan, M. C., Vucic, S., Hodges, J.R. (2011, April). Motor Neuron Dysfunction in Frontotemporal Dementia. Poster session presented at the 63rd Annual Meeting of the American Academy of Neurology, Honolulu, USA.

Further Information

Contact Details

Telephone: +61 2 9850 4127
Email : ccd@mq.edu.au
Web : www.ccd.edu.au

Sign up to receive CCD event and research announcements

Upcoming CCD Seminars

Full Seminar List


Macquarie Univeristy Logo University of Western Australia Logo The University of Sydney Logo

University of New South Wales Logo University of New England logo