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Dr Cristian Leyton

BMed USACH, GradDipNeuro PUC, PhD UNSW.

Associate Investigator

Contact Details

email : cristian.leyton@sydney.edu.au
Homepage : http://sydney.edu.au/health-sciences/about/people/profiles/cristian.leyton.php
ORCID : http://orcid.org/0000-0002-8236-6561

External Address

Faculty of Health Sciences
The University of Sydney

Profile

Dr Cristian Leyton completed his PhD at UNSW in 2012. He is currently appointed as a University Postdoctoral Fellow at the Faculty of Health Sciences of The University of Sydney and as an Honorary Associate position at Neuroscience Research Australia. His research focuses on Primary Progressive Aphasia (PPA), with a particular interest in the logopenic variant. He is looking at ways to identify PPA cases caused by Alzheimer’s disease and develop strategies to improve lexical retrieval in these patients.

Awards

  • UNSW School of Medical Sciences, Paper of the Month Award (2014), Kumfor, F., Sapey-Triomphe, L.-A., Leyton, C.E., Burrell, J.R., Hodges, J.R., & Piguet, O. For the publication: Kumfor, F., et al. (2014) "Degradation of emotion processing ability in corticobasal syndrome and Alzheimer's disease" in Brain.

Recent Grants Awarded

  • NHMRC-ARC Dementia Research Development Fellowship [APP1102969] (2016 - 2019) "Disentangling aphasic syndromes in Alzheimer's disease." Leyton, C. ($682,936)
  • The University of Sydney Postdoctoral Research Fellowship - Faculty of Health Sciences (2014 - 2016) "Differentiation and treatment for nonfluent variants of Primary Progressive Aphasia." Leyton, C., & Ballard, K. ($361,000)

Selected Publications

Book Chapters

  • Leyton, C.E., & Hodges, J.R. (2015). Differential diagnosis of primary progressive aphasia variants using the international criteria. In L. Nickels & K. Croot (Eds.), Clinical Perspectives on Primary Progressive Aphasia (pp. 25-37). Hove, UK: Psychology Press.
  • Piguet, O., Leyton, C., & Hodges, J.R. (2014). Frontotemporal dementia and other related dementias. In G. Caplan (Ed.), Geriatric medicine: A guide to practice (pp. 108-124). Melbourne: IP Communications.

Periodicals

  • Kumfor, F., Leyton, C.E., & Piguet, O. (2017). Letter re: Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence. Neurology, 88(16), 1590. doi:10.1212/WNL.0000000000003855
  • Landin-Romero, R., Kumfor, F., Leyton, C.E., Irish, M., Hodges, J.R., & Piguet, O. (2017). Disease-specific patterns of cortical and subcortical degeneration in a longitudinal study of Alzheimer's disease and behavioural-variant frontotemporal dementia. NeuroImage, 151, 72-80. doi:10.1016/j.neuroimage.2016.03.032
  • Leyton, C.E., Hodges, J.R., Piguet, O., & Ballard, K.J. (2017). Common and divergent neural correlates of anomia in amnestic and logopenic presentations of Alzheimer's disease. Cortex, 86, 45-54.
  • Van Langenhove, T., Piguet, O., Burrell, J.R., Leyton, C., Foxe, D., Abela, M., Bartley, L., Kim, W.S., Jary, E., Huang, Y., Dobson-Stone, C., Kwok, J.B., Halliday, G.M., & Hodges, J.R. (2017). Predicting development of amyotrophic lateral sclerosis in frontotemporal dementia. Journal of Alzheimer's Disease, 58, 163-170. doi:10.3233/JAD-161272
  • Foxe, D., Leyton, C.E., Hodges, J.R., Burrell, J.R., Irish, M., & Piguet, O. (2016). The neural correlates of auditory and visuospatial span in logopenic progressive aphasia and Alzheimer's disease. Cortex, 83, 39-50. doi:10.1016/j.cortex.2016.07.003
  • Hsieh, S., Leyton, C.E., Caga, J., Flanagan, E., Kaizik, C., O'Connor, C.M., Kiernan, M.C., Hodges, J.R., Piguet, O., & Mioshi, E. (2016). The evolution of caregiver burden in frontotemporal dementia with and without amyotrophic lateral sclerosis. Journal of Alzheimer's Disease, 49(3), 875-885. doi:10.3233/JAD-150475
  • Leyton, C., Britton, A.K., Hodges, J.R., Halliday, G.M., & Kril, J.J. (2016). Distinctive pathological mechanism involved in primary progressive aphasias. Neurobiology of Aging, 38, 82-92. doi:10.1016/j.neurobiolaging.2015.10.017
  • Leyton, C.E., & Ballard, K.J. (2016). Primary progressive aphasia: Conceptual evolution and challenges. Neuroscience and Neuroeconomics, 5, 9-18. doi:10.2147/NAN.S102848
  • Leyton, C.E., Cassidy, B., Villemagne, V.L., Jones, G., Kwok, J.B., Rowe, C.C., Ballard, K.J., Piguet, O., & Hodges, J.R. (2016). Divergent network patterns of amyloid-ß deposition in logopenic and amnestic Alzheimer’s disease presentations. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1(1), 24-31. doi:10.1016/j.bpsc.2015.09.004
  • Lillo, P.Z., & Leyton, C.E. (2016). [“Demencia Frontotemporal como ha resurgido su diagnóstico”]. How the diagnosis of frontotemporal dementia has resurged. Revista Médica Clínica Las Condes, 27(3), 309-318.
  • Midorikawa, A., Leyton, C.E., Foxe, D., Landin-Romero, R., Hodges, J.R., & Piguet, O. (2016). All is not lost: Positive behaviors in Alzheimer's disease and behavioral-variant frontotemporal dementia with disease severity. Journal of Alzheimer's Disease, 54(2), 549-558. doi:10.3233/JAD-160440
  • O'Connor, C.M., Clemson, L., Hornberger, M., Leyton, C.E., Hodges, J.R., Piguet, O., & Mioshi, E. (2016). Longitudinal change in everyday function and behavioral systems in frontotemporal dementia. Neurology: Clinical Practice, 6(5), 419-428.
  • Ramanan, S., Flanagan, E., Leyton, C.E., Villemagne, V.L., Rose, C.C., Hodges, J.R., & Hornberger, M. (2016). Non-verbal episodic memory deficits in primary progressive aphasias are highly predictive of underlying amyloid pathology. Journal of Alzheimer's Disease, 51(2), 367-376. doi:10.3233/JAD-150752
  • Schubert, S., Leyton, C.E., Hodges, J., & Piguet, O. (2016). Longitudinal memory profiles in behavioral-variant frontotemporal dementia and Alzheimer’s disease. Journal of Alzheimer's Disease, 51(3), 775-782. doi:10.3233/JAD-150802
  • Tu, S., Leyton, C., Hodges, J., Piguet, O., & Hornberger, M. (2016). Divergent longitudinal propagation of white matter degradation in logopenic and semantic variants of primary progressive aphasia. Journal of Alzheimer's Disease, 49(3), 853-861. doi:10.3233/JAD-150626
  • Van Langenhove, T., Leyton, C.E., Piguet, O., & Hodges, J.R. (2016). Comparing longitudinal behavior changes in the primary progressive aphasias. Journal of Alzheimer's Disease, 53(3), 1033-1042. doi:10.3233/JAD-160010
  • Leyton, C.E., Hodges, J.R., McLean, C.A., Kril, J.J., Piguet, O., & Ballard, K. (2015). Is the logopenic-variant of primary progressive aphasia a unitary disorder? Cortex, 67, 122-133. doi:10.1016/j.cortex.2015.03.011
  • Ossenkoppele, R., Jansen, W.J., Rabinovici, G.D., Knol, D.L., van der Flier, W.M., van Berckel, N.M., Scheltens, P., Jelle Visser, P., and the Amyloid PET Study Group (including Hodges, J.R., Leyton, C.E.) (2015). Prevalence of Amyloid PET Positivity in Dementia Syndromes. The Journal of the American Medical Association, 313(19), 1939-1949.
  • Piguet, O., Leyton, C.E., Gleeson, L., Hoon, C., & Hodges, J.R. (2015). Memory and emotion processing performance contributes to the diagnosis of non-semantic primary progressive aphasia syndromes. Journal of Alzheimer's Disease, 44(2), 541-547. doi:10.3233/JAD-141854
  • Taswell, C., Villemagne, V.L., Yates, P., Shimada, H., Leyton, C.E., Ballard, K.J., Piguet, O., Burrell, J.R., Hodges, J.R., & Rowe, C.C. (2015). FDG-PET improves diagnosis in patients presenting with focal onset dementias. The Journal of Nuclear Medicine, 56, 1547-1553. doi:10.2967/jnumed.115.161067
  • Ballard, K.J., Savage, S., Leyton, C.E., Vogel, A.P., Hornberger, M., & Hodges, J.R. (2014). Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production. PLoS ONE, 9(2), e89864. doi:10.1371/journal.pone.0089864
  • Chare, L., Hodges, J.R., Leyton, C.E., McGinley, C., Tan, R.H., Kril, J.J., & Halliday, G.M. (2014). New criteria for frontotemporal dementia syndromes: Clinical and pathological implications. Journal of Neurology, Neurosurgery and Psychiatry, 85, 866–871. doi:10.1136/jnnp-2013-306948
  • Kumfor, F., Irish, M., Leyton, C., Miller, L., Lah, S., Devenney, E., Hodges, J.R., & Piguet, O. (2014). Tracking the progression of social cognition in neurodegenerative disorders. Journal of Neurology, Neurosurgery and Psychiatry, 85(10), 1076-1083. doi: 10.1136/jnnp-2013-307098
  • Kumfor, F., Sapey-Triomphe, L.-A., Leyton, C.E., Burrell, J.R., Hodges, J.R., & Piguet, O. (2014). Degradation of emotion processing ability in corticobasal syndrome and Alzheimer’s disease. Brain, 137(11), 3061-3072. doi:10.1093/brain/awu246
  • Leyton, C.E., & Hodges, J.R. (2014). Review: Differential diagnosis of primary progressive aphasia variants using the international criteria. Aphasiology, 28(8-9), 909-921. doi:10.1080/02687038.2013.869306
  • Leyton, C.E., Ballard, K.J., Piguet, O., & Hodges, J.R. (2014). Phonologic errors as a clinical marker of the logopenic variant of PPA. Neurology, 82, 1620-1627.
  • Leyton, C.E., Savage, S., Irish, M., Schubert, S., Piguet, O., Ballard, K.J., & Hodges, J.R. (2014). Verbal repetition in primary progressive aphasia and Alzheimer’s disease. Journal of Alzheimer's Disease, 41(2), 575-585. doi: 10.3233/JAD-132468
  • Leyton, C., & Hodges, J.R. (2013). Towards a clearer definition of logopenic progressive aphasia. Current Neurology and Neuroscience Reports, 13(11), 396. doi:10.1007/s11910-013-0396-6
  • Leyton, C.E., Hsieh, S., Mioshi, E., & Hodges, J.R. (2013). Cognitive decline in logopenic aphasia: More than losing words. Neurology, 80(10), 897-903. doi:10.1212/WNL.0b013e318285c15b
  • Croot, K., Ballard, K., Leyton, C., & Hodges, J.R. (2012). Apraxia of speech and phonological errors in the diagnosis of nonfluent/agrammatic and logopenic variants of primary progressive aphasia. Journal of Speech, Language, and Hearing Research, 55(5), S1563-S1572. doi:10.1044/1092-4388(2012/11-0323)
  • Hsieh, S., Hodges, J.R., Leyton, C., & Mioshi, E. (2012). Longitudinal changes in Primary Progressive Aphasias: Differences in cognitive and dementia staging measures. Dementia and Geriatric Cognitive Disorders, 34, 135–141. doi:10.1159/000342347
  • Jimenez-Cohl, P., Grekin, C., Leyton, C., Vargas, C., & Villaseca, R. (2012). Thermal threshold: research study on small fiber dysfunction in distal diabetic polyneuropathy. Journal of Diabetes Science and Technology, 6(1), 177-183.
  • Leyton, C.E., Piguet, O., Savage, S., Burrell, J., & Hodges, J.R. (2012). The neural basis of Logopenic Progressive Aphasia. Journal of Alzheimer's Disease, 32(4), 1051–1059.
  • Leyton, C.E., Villemagne, V.L., Savage, S., Pike, K.E., Ballard, K.J., Piguet, O., Burrell, J.R., Rowe, C.C., & Hodges, J.R. (2011). Subtypes of progressive aphasia: Application of the international consensus criteria and validation using B-amyloid imaging. Brain, 134(10), 3030-3043.

Published Abstracts

  • Landin-Romero, R., Kumfor, F., Leyton, C., Irish, M., Hodges, J., & Piguet, O. (2016). Disease-specific patterns of cortical and subcortical degeneration in a longitudinal study of Alzheimer's disease and behavioural-variant frontotemporal dementia [Abstract]. Journal of Neurochemistry, 138(Suppl. 1), 376. doi:10.1111/jnc.13692
  • Leyton, C., Hodges, J., Piguet, O., & Ballard, K. (2016). Common and divergent neural correlates of anomia in amnestic and logopenic presentations of Alzheimer's disease [Abstract]. Journal of Neurochemistry, 138(Suppl. 1), 352. doi:10.1111/jnc.13692
  • Leyton, C., Hodges, J., Piguet, O., & Ballard, K. (2016). Dissecting neurocognitive mechanisms underpinning sentence-processing deficits in PPA [Abstract]. Journal of Neurochemistry, 138(Suppl. 1), 352.
  • Leyton, C., Landin-Romero, R., Kumfor, F., Burrell, J., Hodges, J.R., & Piguet, O. (2016). Convergent language network involvement in non-semantic PPA variants [Abstract]. Journal of Neurochemistry, 138(Suppl. 1), 352. doi:10.1111/jnc.13692
  • Taswell, C., Villemagne, V., Yates, P., Shimada, H., Leyton, C., Ballard, K., Piguet, O., Burrell, J., Hodges, J., & Rowe, C. (2014). FDG-PET improves diagnosis in patients presenting with focal onset variants of Alzheimer’s disease [Abstract]. The Journal of Nuclear Medicine, 55(Suppl. 1), 194.

Conference Presentations, Colloquia, and other presentations

  • Hsieh, S., Leyton, C., Caga, J., Flanagan, E., Kaizik, C., O’Connor, C.M., Kiernan, M.C., Hodges, J.R., Piguet, O., & Mioshi, E. (2015, December). The experience of burden over time in frontotemporal dementia and motor neuron disease. Paper presented at the 26th International Symposium ALS/MND, Orlando, USA.
  • Etter, N., Charters, E., Leyton, C., & Ballard, K.J. (2015, November). A case study using perispinal injections of etanercept to treat chronic brain injury Poster session presented at the American Speech-Language-Hearing Association Convention (ASHA), Denver, USA.
  • Leyton, C., & Ballard, K.J. (2015, November). Dissection neurocognitive mechanisms underpinning grammatical deficits in Primary Progressive Aphasias. Paper presented at the American Speech-Language-Hearing Association Convention (ASHA), Denver, USA.
  • Van Langenhove, T., Leyton, C.E., Piguet, O., & Hodges, J.R. (2015, November). Differences in prevalence and course of behaviour changes between subtypes of primary progressive aphasia. Poster session presented at the ARC Centre of Excellence in Cognition and its Disorders Annual Workshop, Macquarie University, Sydney.
  • Van Langenhove, T., Leyton, C.E., Piguet, O., & Hodges, J.R. (2015, October). Differences in the prevalence and course of behaviour changes between subtypes of primary progressive aphasia. Poster session presented at the Asia Pacific FTD/MND (APFM) Meeting, The University of Sydney, Sydney.
  • Ramanan, S., Flanagan, E., Leyton, C.E., Villemagne, V.L., Rowe, C.C., Hodges, J.R., & Hornberger, M. (2015, September). Non-verbal episodic memory deficits in primary progressive aphasias are predictive of underlying amyloid pathology. Poster session presented at the 5th Conference of the European Societies of Neuropsychology, Tampere, Finland.
  • Leyton, C.E., Piguet, O., Lam, B., Hodges, J., & Ballard, K. (2014, October). Dissecting naming impairments in the logopenic variant of primary progressive aphasia. Poster session presented at the 9th International Conference on Frontotemporal Dementias, Vancouver, Canada.
  • Leyton, C. (2014, August). Dissecting impaired naming in logopenic progressive aphasia. Paper presented at the ARC Centre of Excellence in Cognition and its Disorders Annual Workshop, Macquarie University, Sydney.
  • Ballard, K., Leyton, C.E., Vogel, A., Savage, S., & Hodges, J. (2013, November). Logopenic and nonfluent primary progressive aphasia are reliably differentiated by acoustic measures of speech production. Poster session presented at the American Speech-Language-Hearing Association (ASHA) Convention, Chicago, USA.
  • Leyton, C.E., Ballard, K., Piguet, O., & Hodges J. (2013, November). Phonological errors as a specific clinical marker of logopenic aphasia. Poster session presented at the ARC Centre of Excellence in Cognition and its Disorders (CCD) Annual Workshop, Macquarie University, Sydney.
  • Foxe, D., Irish, M., Leyton, C., Hodges, J.R., & Piguet, O. (2013, October). Platform paper: The neural correlates of verbal and visuospatial span in logopenic progressive aphasia and Alzheimer’s disease. Paper presented at the 19th Annual College of Clinical Neuropsychology Conference, Brisbane.
  • Kumfor, F., Irish, M., Leyton, C., Devenney, E., Hodges, J.R., & Piguet O. (2013, October). Tracking the progression of emotional disturbance in neurodegenerative disorders. Paper presented at the 19th Annual Australian Psychological Society (APS) College of Clinical Neuropsychologists Conference, Brisbane.
  • Kumfor, F., Irish, M., Leyton, C., Devenney, E., Hodges, J.R., & Piguet, O. (2013, October). Social functioning decline distinguishes behavioural-variant frontotemporal dementia and Alzheimer’s disease. Poster session presented at the 8th Annual Brain Sciences University of New South Wales (UNSW) Symposium: "The Interactive Brain: Translational Neuroscience", Sydney.
  • Leyton, C., Piguet, O., Savage, S., Burrell, J., & Hodges, J.R. (2012, September). Neural correlates of impaired naming and repetition in logopenic progressive aphasia. Poster session presented at the 8th International Conference on Frontotemporal Dementias, Manchester, UK.

Further Information

Contact Details

Telephone: +61 2 9850 4127
Email : ccd@mq.edu.au
Web : www.ccd.edu.au

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